Cxcr4 CLIA Kit for Mouse(Mus musculus) | EIAab.comCxcr4 CLIA Kit for Mouse(Mus musculus)

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Cxcr4 (Gene name),

C-X-C chemokine receptor type 4 (Protein name ), CXCR4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cxcr4(Cmkar4;Lestr;Sdf1r);

Protein name:

C-X-C chemokine receptor type 4(CXC-R4;CXCR-4);

Alternative:

Leukocyte-derived seven transmembrane domain receptor(LESTR);Fusin;Stromal cell-derived factor 1 receptor(SDF-1 receptor);Pre-B-cell-derived chemokine receptor(PB-CKR);

CD:

CD184;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer (By similarity). Can form dimers (By similarity). Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels (By similarity). Interacts with CD164.

Function:

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Subcellular Location:

Cell membrane Multi-pass membrane protein In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.

Protein Attributes:

Sequence length:

359

Sequence:

50:

100:

150:

200:

250:

300:

350:

359:

SESSSFHSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12767

Pfam:

PF00001

UniGene:

Mm.1401

SMR:

P70658

String:

P70658

Uniprot:

P70658

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ELISA Kit for Mouse CXC-R4

Cat.:

E2170h

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96T

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ELISA Kit for Mouse CXC-R4

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E2170p

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96T

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ELISA Kit for Mouse CXC-R4

Cat.:

E2170b

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96T

ELISA Kit for Mouse CXC-R4

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E2170m

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96T

ELISA Kit for Mouse CXC-R4

Cat.:

E2170d

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96T

ELISA Kit for Mouse CXC-R4

Cat.:

E2170r

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96T

CLIA Kit for Mouse CXC-R4

Cat.:

U2170p

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96T

CLIA Kit for Mouse CXC-R4

Cat.:

U2170b

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96T

CLIA Kit for Mouse CXC-R4

Cat.:

U2170m

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96T

CLIA Kit for Mouse CXC-R4

Cat.:

U2170h

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Looking for manual.

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96T

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CLIA Kit for Mouse CXC-R4

Cat.:

U2170r

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96T

CLIA Kit for Mouse CXC-R4

Cat.:

U2170d

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96T

Polyclonal Antibody for Mouse CXC-R4

Cat.:

P2170Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse CXC-R4

Cat.:

P2170Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse CXC-R4

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P2170Rb-m

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Monoclonal Antibody for Mouse CXC-R4

Protein for Mouse CXC-R4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor."
Heesen M. , Berman M.A. , Benson J.D. , Gerard C. , Dorf M.E.
J. Immunol.157:5455-5460(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM CXCR4-B)
strain: 129/Sv.
strain: C57BL/6J.
tissue: Peritoneal exudate.
2.

"Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin."
Nagasawa T. , Nakajima T. , Tachibana K. , Iizasa H. , Bleul C.C. , Yoshie O. , Matsushima K. , Yoshida N. , Springer T.A. , Kishimoto T.
Proc. Natl. Acad. Sci. U.S.A.93:14726-14729(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B)
tissue: Pre-B cell.
3.

Schubel A. , Burgstahler R. , Lipp M.
Submitted (1996-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B)
strain: 129/Sv.
tissue: Thymus.
4.

"Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo."
Moepps B. , Frodl R. , Rodewald H.-R. , Baggiolini M. , Gierschik P.
Eur. J. Immunol.27:2102-2112(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS CXCR4-A AND CXCR4-B)
strain: C57BL/6J X CBA/J.
tissue: Thymus.
5.

"Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms."
Heesen M. , Berman M.A. , Hoepken U.E. , Gerard N.P. , Dorf M.E.
J. Immunol.158:3561-3564(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CXCR4-A AND CXCR4-B)
6.

Suzuki G. , Nakata Y. , Uzawa A. , Shirasawa T. , Saito T. , Mita K.
Submitted (1997-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CXCR4-B)
strain: C57BL/6.
tissue: Thymus.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CXCR4-B)
strain: FVB/N.
tissue: Mammary gland.
8.

"Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
Frodl R. , Gierschik P. , Moepps B.
J. Recept. Signal Transduct.18:321-344(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
9.

"The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract."
Tachibana K. , Hirota S. , Iizasa H. , Yoshida H. , Kawabata K. , Kataoka Y. , Kitamura Y. , Matsushima K. , Yoshida N. , Nishikawa S. , Kishimoto T. , Nagasawa T.
Nature393:591-594(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
10.

"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development."
Zou Y.-R. , Kottmann A.H. , Kuroda M. , Taniuchi I. , Littman D.R.
Nature393:595-599(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
11.

"Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice."
Ma Q. , Jones D. , Borghesani P.R. , Segal R.A. , Nagasawa T. , Kishimoto T. , Bronson R.T. , Springer T.A.
Proc. Natl. Acad. Sci. U.S.A.95:9448-9453(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
12.

"Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4."
McGrath K.E. , Koniski A.D. , Maltby K.M. , McGann J.K. , Palis J.
Dev. Biol.213:442-456(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
strain: ICR.
13.

"Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."
Bae G.-U. , Gaio U. , Yang Y.-J. , Lee H.-J. , Kang J.-S. , Krauss R.S.
J. Biol. Chem.283:8301-8309(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD164

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